Eliciting B cell immunity against infectious diseases using nanovaccines

Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity

H5N1 avian influenza is a significant global concern with the potential to become the next pandemic threat. Recombinant subunit vaccines are an attractive alternative for pandemic vaccines compared to traditional vaccine technologies. In particular, polyanhydride nanoparticles encapsulating subunit proteins have been shown to enhance humoral and cell-mediated immunity and provide protection upo...

Targeted nanovaccines against respiratory pathogens

Dendritic Cell-Tumor Fusion Vaccines Immunogenic Tumors by Immunization with Eliciting T Cell Immunity Against Poorly

Cellular Immunity-Pathogen Interactions in Infectious Diseases

The interactions among host immunity, pathogens, and environment are ever-going process of disease and health. In nature, there is an ongoing equilibrium between infectious agents and their susceptible host organisms. While challenge of immune-competent individuals to low pathogenic strains usually results in elimination of the infectious agent, the other host-pathogen matches generally produce...

Interferon Lambda: Modulating Immunity in Infectious Diseases

Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the heterodimeric IFN-λ receptor (IFNLR), activating a STAT phosphorylation-dependent signaling cascade. Thereby hundreds of IFN-stimulated genes are induced, which modulate various immune functions via complex forward and feed...